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U.S. Department of Health and Human Services

Substances Added to Food (formerly EAFUS)

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The Substances Added to Food inventory replaces what was previously known as Everything Added to Foods in the United States (EAFUS).

The Substances Added to Food inventory includes the following types of ingredients regulated by the U.S. Food and Drug Administration (FDA):

  • Food additives and color additives that are listed in FDA regulations (21 CFR Parts 172, 173 and Parts 73, 74, 82 respectively), and flavoring substances evaluated by FEMA* and JECFA*.
    • Note that for a substance to be used as a color additive in the US, it must be authorized by a regulation in 21 CFR Part 73, 74, or 82.
  • Generally Recognized as Safe (“GRAS”) substances that are listed in FDA regulations (21 CFR Parts 182 and 184).
  • Substances approved for specific uses in foods prior to September 6, 1958, known as prior-sanctioned substances (21 CFR Part 181).
  • Substances formerly used:
    • Prohibited substances that are listed in FDA regulations (21 CFR Part 189) as prohibited from use in food (labeled as "PROHIBITED" or "PROHIBITED WITH EXCEPTIONS").
    • Delisted color additives in FDA regulations (21 CFR 81.10 and/or 81.30) (labeled as "DELISTED").
    • Some substances "no longer FEMA GRAS"

It is important to note that the inventory is only a partial list of food ingredients. Inclusion in this inventory of information from non-FDA entities does not indicate an FDA approval or evaluation of this use.

Users also have the option to search multiple food ingredient and packaging inventories at one time. This includes the following substances not listed in the Substances Added to Food inventory:

For more information, please refer to Food Ingredient and Packaging Inventories.


Search and display hints

  • Select the Substance name below to view the additional details about the substance.
  • To sort by a specific field, click on the column header for that field.
  • To browse the records, use the Show All, First/Previous/Next/Last, and Jump To options at the bottom of the data table.
  • To search for a specific term (or phrase or partial word), enter that term in the Search box and select Show Items to display only those records that contain the selected term.
  • The search results may include terms not shown on the results pages, but included in the full record descriptions. For example, a search for “gum Arabic” will find the substance “Acacia”.
  • The search results will return hits of records containing words that include the search term. For example, a search for the color red will return results that include terms such as reducing, ingredient, and denatured.
Download Substances Added to Food <em>(formerly EAFUS)</em> data in Microsoft Excel web format Download data from this searchable database in Excel format. If you need help accessing information in different file formats, see Instructions for Downloading Viewers and Players.
Search within these results
Records Found: 1308 Show All Page 1 of 27
CAS Reg. No.*
(or other ID*)
Substance*
(sorted A-Z)
CEDI*
(µg/kg bw/d)
CDC*
(ppb)
Calculation/ update* Date 21 CFR*
78-63-7 (1,1,4,4-TETRAMETHYLTETRAMETHYLENE)BIS(TERT-BUTYL PEROXIDE)
0.01
0.2
Jun 17, 2010 177.1520
177.2600
68259-36-9 (2,4,4-TRIMETHYLPENT-2-YL)-N-PHENYL-1-NAPHTHYLAMINE
2.5
50
Jul 24, 2007
6891-44-7 (2-(METHACRYLOYLOXY)ETHYL)TRIMETHYLAMMONIUM METHYL SULFATE
0.02
0.4
Sep 6, 2000 173.10
178.3520
68784-12-3 (2-ALKENYL(C15-21))SUCCINIC ANHYDRIDE
2.6
52
Oct 23, 2015 176.170
26401-86-5 (N-OCTYL)TIN S,S',S''-TRIS(ISOOCTYLMERCAPTOACETATE)
0.385
7.7
Jul 22, 1985
4118-16-5 1,1'-((6-PHENYL-1,3,5-TRIAZINE-2,4-DIYL)DIIMINO)BIS[9,10-ANTHRACENEDIONE]
0.025
0.5
Mar 21, 1985
94-03-1 1,1'-OXYBIS(2-PROPANOL) DIBENZOATE
0.85
17
Jun 20, 2000
1163733-25-2 1,1,2,2-TETRAFLUORO-2-[(1,2,2-TRIFLUOROETHENYL)OXY]ETHANESULFONYL FLUORIDE, POLYMER WITH 1,1,2,2-TETRAFLUOROETHENE, HYDROLYZED
0.0000265
0.00053
Nov 13, 2017
1843-03-4 1,1,3-TRIS(5-TERT-BUTYL-4-HYDROXY-2-METHYLPHENYL)BUTANE
47
940
Nov 7, 1983 175.105
178.2010
75-37-6 1,1-DIFLUOROETHANE
0.55
11
Oct 15, 1992 178.3010
701.30
75-38-7 1,1-DIFLUOROETHENE
0.000035
0.0007
Feb 29, 2000 177.1350
177.1380
177.2510
177.2600
64253-30-1 1,11-(3,6,9-TRIOXAUNDECYL) BIS[3-(DODECYLTHIO)PROPIONATE]
0.6
12
Sep 26, 1996
887192-39-4 1,12,23,34-TETRAAZACYCLOTETRATETRACONTANE-2,11,24,33-TETRONE
0.11
2.2
Aug 19, 2014
143423-02-3 1,12-DIAZACYCLODOCOSANE-2,11-DIONE
1.85
37
Aug 19, 2014
882073-43-0 1,2,3-TRIDEOXY-4,6:5,7-BIS-O-[(4-PROPYLPHENYL)METHYLENE]NONITOL
0.28
5.6
Jul 24, 2008
3319-31-1 1,2,4-BENZENETRICARBOXYLIC ACID, 1,2,4-TRIS(2-ETHYLHEXYL) ESTER
1.5
30
Apr 21, 2017
2855-27-8 1,2,4-TRIVINYLCYCLOHEXANE
0.0005
0.01
Aug 22, 2000
2634-33-5 1,2-BENZISOTHIAZOLIN-3-ONE
8.9
178
Jan 19, 2021 175.105
176.170
176.180
176.300
177.2600
32687-78-8 1,2-BIS(3,5-DI-TERT-BUTYL-4-HYDROXYHYDROCINNAMOYL)HYDRAZINE
11.6
232
Dec 9, 2021 175.105
178.2010
3785-34-0 1,2-BIS(MONOBROMOACETOXY)ETHANE
0.02
0.4
Jun 19, 2000 176.300
16068-37-4 1,2-BIS(TRIETHOXYSILYL)ETHANE
0.016
0.32
Jan 14, 2008
491589-22-1 1,2-CYCLOHEXANEDICARBOXYLIC ACID, CALCIUM SALT
0.6
12
Mar 14, 2006
35691-65-7 1,2-DIBROMO-2,4-DICYANOBUTANE
1.9
38
Feb 2, 1996 175.105
175.300
175.320
176.170
176.210
176.300
113669-58-2 1,2-OCTANEDISULFONIC ACID
0.04
0.8
Jan 7, 1985 178.1010
106990-43-6 1,3,5-TRIAZINE-2,4,6-TRIAMINE, N,N'''-1,2-ETHANEDIYLBIS[N-[3-[[4,6-BIS[BUTYL(1,2,2,6,6-PENTAMETHYL-4-PIPERIDINYL)AMINO]-1,3,5-TRIAZIN-2-YL]AMINO]PROPYL]-N',N''-DIBUTYL-N',N''-BIS(1,2,2,6,6-PENTAMETHYL-4-PIPERIDINYL)-
2.25
45
Mar 30, 1999
7779-27-3 1,3,5-TRIETHYLHEXAHYDRO-1,3,5-TRIAZINE
0.16
3.2
Dec 21, 2000 176.170
177.2600
26175-70-2 1,3,5-TRIS(3,5-DI-TERT-BUTYL-4-HYDROXYHYDROCINNAMOYL)HEXAHYDRO-S-TRIAZINE
0.95
19
Dec 21, 2000 178.2010
40601-76-1 1,3,5-TRIS(4-TERT-BUTYL-3-HYDROXY-2,6-DIMETHYLBENZYL)-1,3,5-TRIAZINE-2,4,6-(1H,3H,5H)-TRIONE
67
1340
May 4, 1981 178.2010
281-86-7 1,3,6,8-TETRAAZATRICYCLO(6.2.1.1(3,6))DODECANE
0.5
10
Sep 6, 2000 176.300
108-45-2 1,3-BENZENEDIAMINE
0.5
10
Sep 9, 2002 177.2280
177.2550
42774-15-2 1,3-BENZENEDICARBOXAMINDE, N,N'-BIS(2,2,6,6-TETRAMETHYL-4-PIPERIDINYL)
10.15
203
Apr 17, 2018
27937-63-9 1,3-BENZENEDICARBOXYLIC ACID, 5-SULFO-, 1,3-DIMETHYL ESTER, SODIUM SALT (1:1), POLYMER WITH DIMETHYL 1,4-BENZENEDICARBOXYLATE AND 1,2-ETHANEDIOL
0.75
15
Oct 3, 2019
888481-50-3 1,3-BENZENEDICARBOXYLIC ACID, 5-SULFO-, 1,3-DIMETHYL ESTER, SODIUM SALT, POLYMER WITH DIMETHYL 1,4-BENZENEDICARBOXYLATE, DIMETHYL PENTANEDIOATE, POLYETHYLENE GLYCOL AND ETHYLENE GLYCOL
1.585
31.7
Oct 20, 2003
130758-99-5 1,3-BENZENEDICARBOXYLIC ACID, POLYMER WITH 1,4-BENZENEDICARBOXYLIC ACID AND 1,2-ETHANEDIOL BLOCK
7
140
Apr 29, 2002
60088-52-0 1,3-BENZENEDICARBOXYLIC ACID, POLYMER WITH 1,4-BENZENEDICARBOXYLIC ACID, (1,1'-BIPHENYL)-4,4'-DIOL AND 4-HYDROXYBENZOIC ACID
1.25
25
Jul 1, 2016
62694-40-0 1,3-BENZENEDICARBOXYLIC ACID, POLYMER WITH AZACYCLOTRIDECAN-2-ONE, 1,4-BENZENEDICARBOXYLIC ACID AND 4,4'-METHYLENEBIS[2-METHYLCYCLOHEXANAMINE]
1.65
33
Nov 18, 2016
106-99-0 1,3-BUTADIENE
0.0009
0.018
Jul 25, 2014 176.180
177.1020
177.1030
177.1050
177.1480
178.3790
68441-13-4 1,3-BUTADIENE, 2-METHYL-, HOMOPOLYMER, OF CIS-1,4-CONFIGURATION, CYCLIZED
0.5
10
Jan 28, 2014
66070-58-4 1,3-BUTADIENE-STYRENE POLYMER, HYDROGENATED
0.05
1
Feb 27, 2007 177.1810
3971-28-6 1,3-CYCLOHEXANEDIMETHANOL
1.5
30
Mar 16, 2010
96-23-1 1,3-DICHLORO-2-PROPANOL
0.0009
0.018
Sep 29, 2004
6228-25-7 1,3-DIOXANE-5,5-DIMETHANOL
0.025
0.5
Feb 18, 2021
136504-96-6 1,3-PROPANEDIAMINE, N,N''-1,2-ETHANEDIYLBIS-, POLYMER WITH N-BUTYL-2,2,6,6-TETRAMETHYL-4-PIPERIDINAMINE AND 2,4,6-TRICHLORO-1,3,5-TRIAZINE
4.5
90
Apr 13, 1998 178.2010
1010121-89-7 1,3-PROPANEDIAMINE, N1-(9Z)-9-OCTADECEN-1-YL-, POLYMER WITH 2-(CHLOROMETHYL)OXIRANE
0.7
14
Oct 2, 2017
55636-09-4 1,3-PROPANEDIAMINIUM, 2-HYDROXY-N1,N1,N1,N3,N3,N3-HEXAMETHYL-, CHLORIDE
0.2167
4.334
Dec 17, 2008
6228-26-8 1,3-PROPANEDIOL, 2,2'-[METHYLENEBIS(OXYMETHYLENE)]BIS[2-(HYDROXYMETHYL)-
0.025
0.5
Feb 18, 2021
126-11-4 1,3-PROPANEDIOL, 2-(HYDROXYMETHYL)-2-NITRO
0.07
1.4
Mar 10, 2008
57609-64-0 1,3-PROPANEDIYL BIS(4-AMINOBENZOATE)
0.01
0.2
Jan 22, 1985 177.1680
82203-23-4 1,3:2,4-BIS-O-[(4-CHLOROPHENYL)METHYLENE]-D-GLUCITOL
1.2
24
Aug 7, 2008
657408-39-4 1,4-BENZENECARBOXYLIC ACID POLYMER WITH 1,10-DECANEDIAMINE AND 1,6-HEXANEDIAMINE
0.00014
0.0028
Feb 23, 2009

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*Definitions

  • CAS Reg. No. (or other ID): Chemical Abstract Service (CAS) Registry Number® for the substance or a numerical code assigned by HFP to those substances that do not have a CAS Registry Number (977nnn-nn-n series).
  • Substance: The name of the ingredient as recognized by HFP.
  • Used for (Technical Effect): The physical or technical effect(s) the substance has in or on food; see 21 CFR 170.3(o) for definitions.
  • 21 CFR: Title 21 of the Code of Federal Regulations.
  • FEMA No.: The trade association, Flavor and Extract Manufacturers Association (FEMA), has established expert panels to evaluate and make independent determinations on the GRAS status of flavoring substances. The FEMA number is provided here as a reference to FEMA’s GRAS assessments.
  • JECFA: The Joint Expert Committee on Food Additives (JECFA) is an international expert scientific committee that is administered jointly by the Food and Agriculture Organization of the United Nations (FAO) and the World Health Organization (WHO). See JECFA Specifications for Flavourings <>

Color Additives

  • For a substance to be used as a color additive in the US, it must be authorized by a regulation in 21 CFR Part 73, 74, or 82.
CAS Reg. No.*
(or other ID*)
Substance*
(sorted A-Z)
CEDI*
(µg/kg bw/d)
CDC*
(ppb)
Calculation/ update* Date 21 CFR*
-
-