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U.S. Department of Health and Human Services

GRAS Notices

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The inventory of GRAS notices provides information about GRAS notices filed since 1998, when FDA received its first GRAS notice. As of October 17, 2016, the GRAS final rule (81 FR 54960; August 17, 2016) requires a specific format for a GRAS notice. Prior to that date, FDA processed GRAS notices under the framework of the GRAS proposed rule (62 FR 18938; April 17, 1997). Notices received prior to the effective date of the GRAS final rule provide examples for potential notifiers for the types of information that may support a GRAS conclusion. In the inventory, notices follow the requirements for the format and content of a GRAS notice as of the effective date of the GRAS final rule.

The inventory notes what type of response letter the FDA sent in response to the notice. Notifiers often resubmit notices that FDA previously ceased to evaluate at the notifier’s request, and resubmitted notices commonly receive a letter indicating FDA has no questions, after addressing deficiencies. In the inventory, entries for notices that were later resubmitted link to the newer entry in the final column. Newer entries for notices that were resubmitted include a link to the previous submission below the substance name.

Some GRNs that FDA previously ceased to evaluate at the notifier’s request were later resubmitted as a food additive petition. For each of these cases, the GRN detail page links to the food additive petition.

After issuing a response letter, we may issue a subsequent letter as circumstances warrant. The issue dates of any subsequent letters are listed under the column, "Date of add’l correspondence.”

We will update this information approximately monthly. More information about this inventory is available on the GRAS Notice Inventory Introduction page.


Search and display hints:

  • Select the specific GRN number below to view additional details about any GRAS Notice.
  • To sort by a specific field, click on the column header for that field.
  • To browse the records, use the Show All, First/Previous/Next/Last, and Jump To options at the bottom of the data table.
  • To search for a specific substance/term, enter the term in the Search box and select Show Items to display only those records that contain the selected term. (The search results also includes terms not shown on this page, but included in the full record on the detail page.)
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Records Found: 1194 Show All Page 1 of 24
GRN No.
(sorted Z-A)
Substance Date of closure FDA's Letter Date of add'l correspondence Resubmitted as GRN No.
  1194
Partially hydrolyzed eggshell membrane powder derived from chicken eggs Pending
  1193
D-psicose Pending
  1192
Tannase enzyme preparation produced by Aspergillus oryzae Pending
  1191
Ergothioneine produced by Escherichia coli BL-21 (DE3) expressing ergothioneine synthases from Schizosaccharomyces pombe Pending
  1190
Saccharomyces cerevisiae strain OYR-481 expressing a gene encoding acetolactate decarboxylase from Brevibacillus brevis Pending
  1189
Dry whole goat milk Pending
  1188
D-psicose Pending
  1187
Polygalacturonase enzyme preparation produced by Trichoderma reesei expressing a gene encoding polygalacturonase from Aspergillus luchuensis mut kawachii Pending
  1110
  1186
Fungal oil (≥38% arachidonic acid (ARA)) from Mortierella alpina FJRK-MA01 Pending
  1185
Algal oil (≥35% docosahexaenoic acid) from Schizochytrium sp. FJRK-SCH3 Pending
  1184
Rebaudioside M from a modified strain of Escherichia coli BL21(DE3) Pending
  1183
Monellin preparation produced by Komagataella phaffii P-MON-040 expressing a gene encoding for a modified monellin Pending
  1182
Hydroxytyrosol Pending
  1138
  1181
Weizmannia coagulans LMG S-31876 spore preparation Pending
  1180
Cellobiose Pending
  1179
Liquid whole cow milk Pending
  1178
Rebaudioside I obtained by enzymatic treatment of steviol glycosides purified from the leaves of Stevia rebaudiana (Bertoni) Bertoni (rebaudioside I) Pending
  1177
Bacillus coagulans “Unique IS-2” spore preparation Pending
  1176
Lacto-N-tetraose Pending
  1175
Lactiplantibacillus plantarum DSM 23881 Pending
  1174
Dry whole goat milk Pending
  1173
Invertase enzyme preparation produced by Trichoderma reesei expressing a gene for invertase from Aspergillus niger Pending
  1172
Liquid milk, either whole or nonfat, combined with lactose and water Pending
  1171
Non-animal type 21 collagen polypeptide Pending
  1170
Resistant dextrin from tapioca in powder or syrup form Pending
  1169
6′-sialyllactose sodium salt Pending
  1168
Tigernuts flour Pending
  1167
Brazzein produced by Komagataella phaffii expressing a gene encoding for brazzein from Pentadiplandra brazzeana Pending
  1166
Fava bean (Vicia faba L.) protein hydrolysate Pending
  1165
(R)-1,3-butanediol Pending
  1164
A chemically synthesized analog of pediocin PA-1 specific to Listeria monocytogenes Pending
  1163
A preparation containing two bacteriophages (phage) specific to Salmonella enterica Pending
  1162
Fungal oil (≥38% arachidonic acid (ARA)) from Mortierella alpina FJRK-MA01 Feb 8, 2024 At the notifier's request, FDA ceased to evaluate this notice (in PDF) (236 kB)
  1161
Triacylglycerol lipase enzyme preparation produced by Candida cylindracea Pending
  1160
Lemna leaf protein Pending
  1159
Bacillus coagulans strain BCP92 spore preparation Pending
  1158
Lactiplantibacillus plantarum DSM 34613 Pending
  1157
2'-fucosyllactose Pending
  1156
Algal oil (≥35% docosahexaenoic acid) from Schizochytrium sp. FJRK-SCH3 Feb 8, 2024 At the notifier's request, FDA ceased to evaluate this notice (in PDF) (204 kB)
  1155
1-methylcyclopropene complex Apr 23, 2024 FDA has no questions (in PDF) (208 kB)
  1154
Triacylglycerol lipase enzyme preparation produced by Komagataella phaffii expressing the gene encoding lipase from Fusarium oxysporum Pending
  1153
Pongamia bean oil Pending
  1152
Phoenix oyster mushroom (Pleurotus pulmonarius) mycelia biomass Pending
  1151
Fava bean protein Pending
  1150
Triacylglycerol lipase enzyme preparation produced by Trichoderma reesei expressing a gene for triacylglycerol lipase from Thermomyces lanuginosis Pending
  1149
High-selenium Saccharomyces cerevisiae yeast Dec 12, 2023 At the notifier's request, FDA ceased to evaluate this notice (in PDF) (98 kB)
  1148
D-psicose Pending
  1147
Copper(II) ion Pending
  1146
Nuclease enzyme preparation produced by Bacillus amyloliquefaciens expressing the gene encoding a nuclease from Serratia marcescens Jun 12, 2024 FDA has no questions (in PDF) (181 kB)
  1145
β-lactoglobulin produced by Aspergillus oryzae strain Ao_st0002 Pending

Show All 

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GRN No.
(sorted Z-A)
Substance Date of closure FDA's Letter Date of add'l correspondence Resubmitted as GRN No.
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